Fatigue is one of the most disabling symptoms in post-viral syndromes such as Post- COVID Syndrome (PCS) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Despite its prevalence, the biological underpinnings of post-viral fatigue remain poorly understood. Increasing evidence points toward neuroinflammation, blood-brain barrier (BBB) dysfunction, and immune infiltration as central mechanisms. The project is part of the "All Eyes on PCS" study. 

Position description (Full description in the appendix​)  We are seeking a highly motivated student to support a translational research project focused on modeling BBB dysfunction and neuroimmune interactions in post-viral fatigue syndromes. You can  join a dynamic and interdisciplinary team (clinical part and basic science part) exploring how viral antigens, immune cells, and neurodegenerative peptides interact to disrupt BBB integrity and contribute to CNS inflammation. As part of the team, the student will engage in a range of experimental tasks, including co-culture modeling of the neurovascular unit, immune cell transmigration assays, and molecular characterization of cellular responses. This work will contribute to the understanding of fatigue pathomechanisms in ME/CFS and PCS and potentially inform therapeutic strategies.

Student Research Roles The student will be actively involved in all phases of the project, including: -  Reading and reviewing relevant scientific literature to support experimental design and interpretation. - Performing laboratory experiments (inculding cell culture experiments, FACS analysis, isolating and stimulating cells, working with HUVECs, retinal endothelial cells)  - Collecting and analyzing data -  Evaluating experimental results critically and participating in troubleshooting. - Contributing to the preparation of reports, presentations, and potentially manuscripts based on the findings.

- At least six months of full-time work would be benifical for the project, though it is not strictly required.

We Offer - Opportunity to gain hands-on experience in a cutting-edge interdisciplinary research project with clinical relevance. - Supervision and training in advanced in vitro modeling techniques and molecular analyses. -  An inclusive and supportive working environment in a well-connected research institute.

- Provision of financial support during periods of full-time work.

Please write an email with your CV and a motivational letter to : andrea.sof@gmail.com, Isabelle.Lethen@mri.tum.de, Timon.Kuchler@mri.tum.de